CUTANEOUS HEAT AND COLD RECEPTORS WITH SLOWLY CONDUCTING (C) AFFERENT FIBRES

Cutaneous Afferent Nerve Activity

I The activity produced by intra-arterial bradykinin and prostaglandin El was investigated in multifibre strands dissected from the saphenous nerves of anaesthetized rats. 2 Bradykinin (0.5-10 gg) alone produced little activity in nerve strands but produced considerable activity following a 10 min infusion, but not a single injection, of prostaglandin E1 (5-100 ng). 3 Prostaglandin E1 alone pro...

Multifunctional conducting fibres with electrically controlled release of ciprofloxacin.

We hereby present a new method of producing coaxial conducting polymer fibres loaded with an antibiotic drug that can then be subsequently released (or sustained) in response to electrical stimulation. The method involves wet-spinning of poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) fibre, which served as the inner core to the electropolymerised outer shell layer of polypy...

Fast-conducting Fibres in the Mitral Valve.

Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder.

It has been proposed that extracellular ATP may be involved in visceral mechanosensory transduction by activating ligand-gated ion channels (P2X receptors). In this study, we have investigated the effects of the P2X(3) agonist alpha,beta-methylene ATP (alpha,beta-meATP) and antagonist 2',3'-O-trinitrophenyl-ATP (TNP-ATP) on pelvic afferents innervating the urinary bladder using an in vitro mous...

Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli.

Positron emission tomography studies have provided evidence for the involvement of the thalamus and cortex in pain and temperature perception. However, the involvement of these structures in pain and temperature perception of individual subjects has not been studied in detail with high spatial resolution imaging. As a first step toward this goal, we have used functional magnetic resonance imagi...